Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease.
Identifieur interne : 000070 ( Main/Exploration ); précédent : 000069; suivant : 000071Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease.
Auteurs : Elijah Mak [Royaume-Uni] ; Li Su [Royaume-Uni] ; Guy B. Williams [Royaume-Uni] ; Michael J. Firbank [Royaume-Uni] ; Rachael A. Lawson [Royaume-Uni] ; Alison J. Yarnall [Royaume-Uni] ; Gordon W. Duncan [Royaume-Uni] ; Brit Mollenhauer [Allemagne] ; Adrian M. Owen [Canada] ; Tien K. Khoo [Australie] ; David J. Brooks [Danemark] ; James B. Rowe [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; John T. O'Brien [Royaume-Uni]Source :
- Neurobiology of aging [ 1558-1497 ] ; 2017.
Abstract
We investigated whole-brain atrophy and ventricular enlargement over 18 months in nondemented Parkinson's disease (PD) and examined their associations with clinical measures and baseline CSF markers. PD subjects (n = 100) were classified at baseline into those with mild cognitive impairment (MCI; PD-MCI, n = 36) and no cognitive impairment (PD-NC, n = 64). Percentage of whole-brain volume change (PBVC) and ventricular expansion over 18 months were assessed with FSL-SIENA and ventricular enlargement (VIENA) respectively. PD-MCI showed increased global atrophy (-1.1% ± 0.8%) and ventricular enlargement (6.9 % ± 5.2%) compared with both PD-NC (PBVC: -0.4 ± 0.5, p < 0.01; VIENA: 2.1% ± 4.3%, p < 0.01) and healthy controls. In a subset of 35 PD subjects, CSF levels of tau, and Aβ42/Aβ40 ratio were correlated with PBVC and ventricular enlargement respectively. The sample size required to demonstrate a 20% reduction in PBVC and VIENA was approximately 1/15th of that required to detect equivalent changes in cognitive decline. These findings suggest that longitudinal MRI measurements have potential to serve as surrogate markers to complement clinical assessments for future disease-modifying trials in PD.
DOI: 10.1016/j.neurobiolaging.2017.03.012
PubMed: 28431288
Affiliations:
- Allemagne, Australie, Canada, Danemark, Royaume-Uni
- Angleterre, Angleterre de l'Est, Grand Londres, Écosse
- Cambridge, Londres, Édimbourg
- Université de Cambridge
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Owen</name><affiliation wicri:level="3"><nlm:affiliation>Brain and Mind Institute, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Brain and Mind Institute, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien K" last="Khoo">Tien K. Khoo</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Health Institute, Queensland and School of Medicine, Griffith University, Gold Coast, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Health Institute, Queensland and School of Medicine, Griffith University, Gold Coast</wicri:regionArea><wicri:noRegion>Gold Coast</wicri:noRegion></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. 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Barker</name><affiliation wicri:level="4"><nlm:affiliation>John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Cambridge, Cambridgeshire, UK. 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Williams</name><affiliation wicri:level="4"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridgeshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridgeshire</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Firbank, Michael J" sort="Firbank, Michael J" uniqKey="Firbank M" first="Michael J" last="Firbank">Michael J. Firbank</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Lawson, Rachael A" sort="Lawson, Rachael A" uniqKey="Lawson R" first="Rachael A" last="Lawson">Rachael A. Lawson</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison J" last="Yarnall">Alison J. Yarnall</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon W" last="Duncan">Gordon W. Duncan</name><affiliation wicri:level="3"><nlm:affiliation>Medicine of the Elderly, Western General Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medicine of the Elderly, Western General Hospital, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena-Klinik, Kassel, Germany; University Medical Center Goettingen, Institute of Neuropathology, Goettingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel, Germany; University Medical Center Goettingen, Institute of Neuropathology, Goettingen</wicri:regionArea><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M" last="Owen">Adrian M. Owen</name><affiliation wicri:level="3"><nlm:affiliation>Brain and Mind Institute, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Brain and Mind Institute, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien K" last="Khoo">Tien K. Khoo</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Health Institute, Queensland and School of Medicine, Griffith University, Gold Coast, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Health Institute, Queensland and School of Medicine, Griffith University, Gold Coast</wicri:regionArea><wicri:noRegion>Gold Coast</wicri:noRegion></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neuroscience, Imperial College London, London, UK; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Division of Neuroscience, Imperial College London, London, UK; Institute of Clinical Medicine, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, James B" sort="Rowe, James B" uniqKey="Rowe J" first="James B" last="Rowe">James B. Rowe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><affiliation wicri:level="4"><nlm:affiliation>John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Cambridge, Cambridgeshire, UK. Electronic address: John.obrien@medschl.cam.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Cambridge, Cambridgeshire</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated whole-brain atrophy and ventricular enlargement over 18 months in nondemented Parkinson's disease (PD) and examined their associations with clinical measures and baseline CSF markers. PD subjects (n = 100) were classified at baseline into those with mild cognitive impairment (MCI; PD-MCI, n = 36) and no cognitive impairment (PD-NC, n = 64). Percentage of whole-brain volume change (PBVC) and ventricular expansion over 18 months were assessed with FSL-SIENA and ventricular enlargement (VIENA) respectively. PD-MCI showed increased global atrophy (-1.1% ± 0.8%) and ventricular enlargement (6.9 % ± 5.2%) compared with both PD-NC (PBVC: -0.4 ± 0.5, p < 0.01; VIENA: 2.1% ± 4.3%, p < 0.01) and healthy controls. In a subset of 35 PD subjects, CSF levels of tau, and Aβ42/Aβ40 ratio were correlated with PBVC and ventricular enlargement respectively. The sample size required to demonstrate a 20% reduction in PBVC and VIENA was approximately 1/15th of that required to detect equivalent changes in cognitive decline. These findings suggest that longitudinal MRI measurements have potential to serve as surrogate markers to complement clinical assessments for future disease-modifying trials in PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li><li>Écosse</li></region><settlement><li>Cambridge</li><li>Londres</li><li>Édimbourg</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mak, Elijah" sort="Mak, Elijah" uniqKey="Mak E" first="Elijah" last="Mak">Elijah Mak</name></region><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon W" last="Duncan">Gordon W. Duncan</name><name sortKey="Firbank, Michael J" sort="Firbank, Michael J" uniqKey="Firbank M" first="Michael J" last="Firbank">Michael J. Firbank</name><name sortKey="Lawson, Rachael A" sort="Lawson, Rachael A" uniqKey="Lawson R" first="Rachael A" last="Lawson">Rachael A. Lawson</name><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T" last="O'Brien">John T. O'Brien</name><name sortKey="Rowe, James B" sort="Rowe, James B" uniqKey="Rowe J" first="James B" last="Rowe">James B. Rowe</name><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><name sortKey="Williams, Guy B" sort="Williams, Guy B" uniqKey="Williams G" first="Guy B" last="Williams">Guy B. Williams</name><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison J" last="Yarnall">Alison J. Yarnall</name></country><country name="Allemagne"><noRegion><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></noRegion></country><country name="Canada"><region name="Angleterre"><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M" last="Owen">Adrian M. Owen</name></region></country><country name="Australie"><noRegion><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien K" last="Khoo">Tien K. Khoo</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28431288
|texte= Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28431288" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |